Abstract
Objective: Telomeres are the distal ends of chromosomes composed of tandem repeats of the sequence TTAGGG. Possible functions of telomeres include prevention of chromosome degradation, end-to-end fusions, rearrangements, and chromosome loss. Telomerase is a ribonucleoprotein that synthesizes telomeric DNA for addition to the end of the chromosome using a segment of its RNA component as a template. Telomerase, counteracts the mitotic clock of telomere shortening. It has been hypothesized that telomerase activity is necessary for cellular immortalization and that telomerase activity is present in cells of germline origin. The objective of the present study was to determine the level of telomerase activity in oocytes and individual blastomere of early embryos, and also to assess the correlation between the telomerase activity and embryo development potential.
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