Abstract
Background: Survivin is a member of the inhibitors of apoptosis gene family that has been implicated in cell division and suppression of apoptosis that becomes expressed in human cancers, e.g. colorectal, bladder cancers. But, there is no available data on the role of survivin in cutaneous neoplasms. Aim: To estimate the expression of survivin gene and protein in Mycosis Fungoides (MF). Methods: Seventeen cases of MF have been en-rolled into this study. Skin biopsies from such patient were subjected to RT-PCR technique to detect the level of survivin gene and protein. Results: There was significant increase in expression of surviving gene and protein in cases of MF if compared to normal control. Conclusion: Survivin may have a role in induction of MF and this may influence the therapeutic strategies for the treatment of MF.
Highlights
Programmed cell death, or apoptosis, is essential for embryonic development and the homeostasis of adult organisms [1]. This involves a dynamic coupling of apoptotic pathways to checkpoint mechanisms that survey cell cycle transitions and eliminate potentially dangerous cells before they progress through mitosis [2]
Survivin is a member of the Inhibitor of Apoptosis (IAP)1 gene family that has been implicated in cell division and suppression of apoptosis and becomes dramatically overexpressed in cancer in response to oncogene activation [4], loss of p53 or deregulated transcription of patterning pathways [5,6]
The aim of this study is to investigate the expression of this novel apoptosis inhibitor gene and protein in one of important cutaneous neoplasms; Mycosis Fungoides (MF)
Summary
Programmed cell death, or apoptosis, is essential for embryonic development and the homeostasis of adult organisms [1]. This involves a dynamic coupling of apoptotic pathways to checkpoint mechanisms that survey cell cycle transitions and eliminate potentially dangerous cells before they progress through mitosis [2]. Survivin is a member of the Inhibitor of Apoptosis (IAP) gene family that has been implicated in cell division and suppression of apoptosis and becomes dramatically overexpressed in cancer in response to oncogene activation [4], loss of p53 or deregulated transcription of patterning pathways [5,6]. There is no available data on the role of survivin in cutaneous neoplasms
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