Expression of scavenger receptor class B, member 2 of death cases infected with enterovirus 71

Abstract

Objective To analyze the clinical data, pathological features, and explore the expression of scavenger receptor class B member 2(SCARB2) of the lung, brain and spinal cord in 9 cases infected with enterovirus71(EV71). Methods The lung, brain and spinal cord tissues and clinical data of 9 cases infected with EV71(EV71 group) were selected as research group, 7 cases who died of accidents were selected as control group.The pathological features were observed by way of hematoxylin and eosin(HE) staining, and the expression of SCARB2 was tested by immunohistochemistry, the integrated optical density(IOD) was detected by using picture analysis software. Results Nine cases had fever, vomiting, startle response, shake, fatigue and pulmonary edema in chest X ray; Congestion, extensive edema and inflammatory cells infiltration in alveolar walls were found in lungs of 9 cases.Transparent membrane was seen obviously in alveolar lumen in 1 case.The brain showed degeneration and necrosis of nerve cells and perivascular cuffing of lymphocytes.Brainstem in 7 cases, brain and spinal cord in 3 cases both revealed cribriform softened, satellitism and neuronophagia, glial nodule.Immunohistochemistry results showed that SCARB2 in EV71 group and the control group were both positive, as the lung tissue IOD values in EV71 group and control group were 4.15×105 and 0.05×105, there was significant difference between the 2 groups(t=108.00, P 0.05). Conclusions The patients mainly died of severe encephalitis, brainstem encephalitis and neurogenic pulmonary edema after EV71 infection.EV71 infection severity and neurotropism may be associated with the high expression of SCARB2. Key words: Enterovirus 71; Scavenger receptor class B member 2; Clinical and pathological features; Immunohistochemistry