Abstract
The presence of C-type retro virus-related proteins in normal or neoplastic human tissues has been described in several studies (for review see [1]). Antigens related to structural proteins of the simian sarcoma-associated virus (SSAV)/gibbon ape leukemia virus (GaLV) primate retrovirus group have been demonstrated in human leukemic cells [2] and placenta [3]. We have previously reported the isolation of a 70-kDa protein from human leukemic sera that cross-reacts with the capsid proteins (CA) of SSAV and baboon endogenous virus (BaEV) [4]. Furthermore, proteins related to the SSAV envelope gp70 protein (SU) seem to be of value in indicating the prognosis of patients with acute leukemia and chronic myelogenous leukemia (CML) in blast crisis [5]. In search of the origin of these proteins, we have identified about 25–35 SSAV-related sequences in the human genome by low stringency hybridization. One of these sequences, S 71, was molecularly cloned and further analyzed [6]. S 71 is a truncated retroviral element with the genomic organization 5-gag-SNRS-pol-LTR-3′ [7, 8]. SNRS represents a region of 1130 bp in S 71 that consists of nonretroviral sequences. Here, we report our studies on the expression of S 71-related sequences in human cell lines and tissues.
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