Abstract
To investigate the expression of retinoic acid receptor β (RAR-β) in human colorectal cancer, RAR-β was detected by immunohistochemistry in normal, adjacent and tumor colorectal tissues of 60 patients suffering from colorectal cancer. The clinicopathological data of these 60 patients were also collected and analyzed. The expression rate of RAR-β in tumor tissues was significantly lower than those of both normal and adjacent tissues. It was also lower in patients with lymph node metastasis and in advanced stage than those without metastasis and in early stage. The expression rate of RAR-β decreases in human colorectal tumor tissues, suggesting RAR-β may be involved in the formation of human colorectal cancer. RAR-β may become a new prognostic indicator of human colorectal cancer. Key words: Colorectal neoplasms, retinoic acid receptors, immunohistochemistry.
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