Expression of resolvin D1 and interleukin-6 in the patients with acute myocardial infarction and reperfusion

Abstract

Objective To investigate the expression and correlation of RvD1 and IL-6 in patients with acute myocardial infarction and reperfusion and its effect on the pathogenesis of acute myocardial infarction and reperfusion. Methods The levels of RvD1 and IL-6 were detected in 30 cases of acute myocardial infarction and 30 cases of normal control group by enzyme linked immunosor-bent assay(ELISA). The 30 patients with acute myocardial infarction received percutaneous coronary intervention(PCI) within 6 hours from admittion. The levels of RvD1 and IL-6 were detected at the time of 2, 4, 12, 24 hours after operations. The correlation of RvD1 with IL-6 was analyzed. Results The levels of RvD1 and IL-6 in patients with acute myocardial infarction and after PCI were significantly higher than those in normal group(P<0.01). In the patients with AMI, compared with before PCI, the levels of RvD1 and IL-6 had increased significantly after 2 hours of PCI(P<0.01), then reached the maximum after 4 hours of PCI (P<0.01), and reduced to the level of pre-operation after 24 hours of PCI. Correlation analysis showed that the level of RvD1 was positively correlated with IL-6. Conclusions RvD1 may play an important role in the pathogenesis of acute myocardial infarction and reperfusion. Key words: Resolvin D1; Interleukin 6; Acute myocardial infarction; Myocardial ischemia reperfusion; Percutaneous coronary intervention