Expression of regenerating gene type Ⅳ in human gastric adenocarcinoma tissues and the clinical significance

Abstract

Objective To investigate the role of regenerating gene typeⅣ(RegⅣ)in the development and progression of gastric adenocarcinoma.Methods S-P immunohistochemistry method was used to detect the expression of RegⅣ,PI3K,and Akt proteins in 63 gastric adenocarcinoma specimens and the corresponding tumor-adjacent normal tissues.Results The positive expression rates of RegⅣ,PI3K and Akt proteins in 63 gastric adenocarcinoma tissues were 50.7%(32/63),68.3%(43/63) and 60.3%(38/63),respectively,being significantly higher than those in the tumor-adjacent normal tissues(19.0%[2/63],20.6%[13/63],and 9.5% [6/63],respectively,P0.05).RegⅣexpression was significantly correlated with the differentiation degree of gastric adenocarcinoma(P0.05)and PI3K protein expression was significantly correlated with the differentiation degree,infiltrative depth,TNM stage and lymph node metastasis of gastric adenocarcinoma(P0.05).Akt protein expression was significantly correlated with lymph node metastasis(P0.05).We also found that Reg Ⅳ protein expression was positively correlated with PI3K and Akt expression(rs=0.284,0.305,P0.05),and PI3K expression was positively correlated with Akt protein expression(rs=0.423,P0.05).Conclusion RegⅣoverexpression is associated with the progression of gastric adenocarcinoma,which may involve activation of PI3K/Akt signaling pathway.