Abstract
Both long and short forms of Prolactin-receptor (PRL-R) mRNA were detected in a spontaneous mammary adenocarcinoma of an aged female F344 rat, using sensitive techniques, reverse transcriptase-polymerase chain reaction (RT-PCR), and in situ hybridization (ISH). Amplified products of the long form of PRL-R were markedly identified by RT-PCR, and the mRNA was diffusely exhibited in the cytoplasm of neoplastic epithelium by ISH. Additionally, the long form of PRL-R mRNA was exhibited in the normal mammary tissue surrounding the neoplasm. However, amplified products of the short form of PRL-R were weakly detected by RT-PCR, and the mRNA was not detected in either normal tissue or the neoplasm by ISH. PRL-R mRNA was detected in the rat spontaneous malignant mammary neoplasm and the long form of PRL-R was more highly expressed than the short form.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
