Abstract
Biocompatibility of new dental sealers should be evaluated before their clinical application.ObjectiveWe studied the in situ production of chemokines in order to evaluate the biocompatibility of five endodontic sealers of different composition (Sealer 26, Tubli‐Seal, MTA, Silverfree AH 26, and Endorez).MethodsBALB/c mice were subcutaneously implanted with the different dental sealers. Then the tissue was prepared for histopathological and immunohistochemical analysis.ResultsThe proinflammatory chemokines CCL3 and CCL4 participated in both, acute and chronic inflammatory response induced by each dental sealer studied. Immunoreactive cells to both chemokines, were observed abundantly in the dermis, especially in the inflamed tissue around the dental sealers. Higher amounts were observed in the acute inflammatory response. According to morphometrical analysis, the order from more to less biocompatible was: MTA, Sealer 26, Tubli‐Seal, Endorez, Silverfree AH26. There were more immunoreactive cells to CCL4 than CCL3 in response to dental sealers (p<0.05).ConclusionsExpression of the proinflammatory chemokines CCL3 and CCL4 is an excellent in vivo model to study the biocompatibility of dental materials. MTA and Sealer 26 are the most biocompatible dental sealers.
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