Abstract
The aim of this work is to evaluate the immunohistochemical expression of PD-L1 in tumor cells of urothelial bladder carcinoma. PD-L1 immunoexpression was assessed on 20 cases of radical cystectomy specimens using monoclonal rabbit anti- PD-L1 antibody. Extent of membranous PD-L1 expression was assigned in each case. Tumor cells showing > 5% expression were considered positive. PD-L1was seen in 6 (30%) cases [1 case score +2 and 5 cases score +3], while 14(70%) cases were negative [7 cases score 0 and 7 cases score +1]. PD-L1 expression in tumor cells was insignificantly correlated with different available clinicopathological parameters such as sex, pathological stage, associatedbilharzial infestation, necrosis, perineural invasion and associated tumor infiltrating mononuclear cells (TIMCs), although PD-L1 positivity tend to predominate in advanced pathological stage of tumor (T3 and T4). These findings may have clinical implications for the management of patients with PD-L1 positive urothelial bladder carcinoma.
Highlights
Urinary bladder carcinoma (UBC) is the ninth most common cancer worldwide and ranks 13th in terms of deaths ranks
This study revealed that no statistical significance between PDL-1 and pathological tumor stage as well as lymph node metastasis
We found positive programmed cell death (PD)-L1 IHC expression in tumor cells was detected in 30% (6 cases) and 70% (14 cases) were negative PD-L1 expression (Table1), this is closely to the study done by [15] who demonstrated that positive PD-L1expression was detected in 20% (32/160) of patients
Summary
Urinary bladder carcinoma (UBC) is the ninth most common cancer worldwide and ranks 13th in terms of deaths ranks. The highest incidence rates observed in North America, Southern and Western Europe as well as in certain countries in Northern Africa or Western Asia. The lowest incidence rates were found in Central and South America, Sub-Saharan Africa, and South East Asia. A strong male predominance is observed with three-quarters of all UBC cases occurring in men [1]. In Egypt, UBC is classified as the third malignancy after breast and colorectal cancers; most cases are urothelial cell carcinomas (78.0%). The major risk factor for bladder carcinoma is cigarette smoking. Certain occupational, industrial exposures and schistosomal infection ( in Egypt) are another major factor [4]
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