Expression of platelet membrane glycoproteins in pediatric idiopathic thrombocytopenic purpura and its clinical significance

Abstract

Objective To explore the relationship between the expression of platelet membrane glycoprotein in pediatric idiopathic thrombocytopenic purpura (ITP) and its clinical significance. Methods A modified monoclonal antibody immobilization of platelet antigen (MAIPA) method was used to detect the positive expression rates of 4 platelet membrane glycoproteins (GPⅠb/Ⅸ, GPⅡb, GPⅢa, and GPⅠb) in 80 pediatric patients with ITP.The correlation was explored between the GP positive rate and the clinical efficacy in pediatric ITP.Trying to observe the correlationship between the GP positive rate of pediatric ITP in the total, the different gender, the acute and chronic and the treatment response rate in pediatric ITP respectively. Results There was a significant difference in curative rate statistically between the GP positive group and the GP negative group(χ2=8.535, P 0.05). Markedly statistic difference was found in the female(χ2=4.433, P 0.05). Conclusions The clinical response rate is significantly correlated with the GP positive rate in pe-diatric ITP, but not correlated with gender.The GP positive rate can reflect the disease status of pediatric ITP to a certain extent and be used as an indicator for judging the efficacy and monitor prognosis of pediatric ITP. Key words: Idiopathic thrombocytopenic purpura; Platelet membrane glycoprotein; Efficacy; Child