Expression of platelet derived growth factor-BB in maintence hemodialysis patients

Abstract

Objective To measure the platelet derived growth factor-BB (PDGF-BB) levels in maintence hemodialysis patients and investigate its significance in carotid atherosclerosis.Methods Sixty-eight patients with hemodialysis were enrolled in this study.Intima-media thickness(IMT) and prevalence of atherosclerotic plaques of the extracranial common carotid artery were measured by echocardiography.The serum PDGF-BB and platelet factor4 (PF4) were measured by enzyme-linked immunosorbent assay in all patients.Results The level of serum PDGF-BB in atherosclerosis group of hemodialysis patients were significantly higher than that in the non-atherosclerotic plaques group [(104 ± 28)pg/ml vs (76 ± 15)pg/ml,P ＜0.01],the level of serum PF4 in atherosclerosis group of hemodialysis patients were significantly higher than that in non-atherosclerotic plaques group[(578 ± 125)ng/L vs (457 ± 60)ng/L,P ＜ 0.05].Multiple stepwise regression analysis indicated that the factor impacting IMT were level of PDGF-BB and age.Conclusions The level of serum PDGF-BB is raised in maintence hemodialysis patients,it maybe play an important role in the formation of carotid atherosclerosis. Key words: Platelet derived growth factor-BB;  Hemodialysis;  Atherosclerosis