Abstract
Abstract Objective This study aimed to investigate the expression and significance of PIN2/TERF1 interacting, telomerase inhibitor 1 (PinX1) and human telomerase reverse transcriptase (hTERT) in basal cell carcinoma (BCC). Methods Real-time polymerase chain reaction and immunohistochemistry were performed to quantify the mRNA expressions and integrated optical density (IOD), respectively, of PinX1 and hTERT in BCC specimens (n = 30), as well as in normal skin specimens (n = 15). Results The mRNA expression level and IOD of PinX1 in the BCC samples were both significantly lower than those in the control specimens (P < 0.05). Conversely, the mRNA expression level and IOD of hTERT in BCC were both significantly higher than that in the control samples (P < 0.05). The correlation between the expression levels of PinX1 and hTERT showed no statistical significance (P > 0.05). Conclusion Downregulation of PinX1 and upregulation of hTERT expression may be associated with the activation and maintenance of telomerases in the induction of BCC.
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