Abstract
Glucagon and β-adrenergic agents increase cAMP levels and stimulate Ca 2+ influx in liver cells. There is no consensus as to the mechanism by which these hormones stimulate the influx of Ca 2+. Using mouse retinal rod CNGCα cDNA probes, we cloned rat liver and skeletal muscle, and human hepatic CNGCα subunit sequences showing 97–100% identity with the human rod channel. In order to assess channel activity, the effect of cyclic nucleotides on free intracellular Ca 2+ levels of isolated hepatocytes was measured. Dibutyryl-cAMP was more effective in increasing free Ca 2+ levels than dibutyryl-cGMP. These data indicate that the CNGCα subunit is expressed in the both liver and skeletal muscle possibly mediating hormonal effects on ion fluxes.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
