Abstract
Lung cancer, especiallysquamous cell carcinoma of lung, is a diseasewhich posesserious threat to human beings. Therefore, more accurate and effective molecular markersshould befoundin order to provide a scientific basis forthe early detection, prognosisprediction and targeted therapyof lung cancer. Phosphatidylethanolamine-binding protein 4 (PEBP4) belongs to the phosphatidylethanolamine binding protein family members, whichnot onlyinhibitsthe MAPK signaling pathway, but also participatesin the inhibition of JNK pathway andpromotion of AKTactivation. It has been recently reported thattheoverexpression of PEBP4 protein is relatedtothe development and metastasis of a variety of tumors. This review discusses the relationship between the expression of PEBP4 and differentiation and metastasis of squamous cell carcinoma of lung. Key words: Lung cancer; Differentiation and metastasis; PEBP4; Signaling pathway
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