Abstract
Objective To investigate the expression of paired box 2 (Pax2) and E-cadherin in human renal cell carcinoma (RCC) and their correlation with clinicopathologic parameters. Methods The RCC tissue microarrays containing 85 renal cell carcinoma specimens and 35 normal kidney tissue specimens were used to detect Pax2 and E-cadherin expressions by immunohistochemistry. Results The positive expression rate of Pax2 was 77.6% (66/85) in RCC specimens, which was significantly higher than that in 35 normal kidney tissue specimens (P 0.05). The expression of E-cadherin in RCC was significantly related to the size of tumor, histological classification, pathological grade and clinical stage (P<0.05). The positive expression rate of E-cadherin in survival group was significantly higher than that in death group (P<0.05). Conclusions The abnormal expressions of Pax2 and E-cadherin may play a crucial stage in development of human RCC. Detection of the expressions of Pax2 and E-cadherin can be used in the evaluation of malignant degree and prognosis of RCC. Key words: PAX2 transcription factor/ME; Cadherins/ME; Kidney neoplasms/ME
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