Abstract
Maintaining genomic integrity in sperm is vital for birth of healthy offspring. Sperm DNA damage is proposed to be a major cause of idiopathic infertility. Sperm DNA damage is associated with poor assisted reproductive technique (ART) outcome. DNA damage triggers modifications of proteins by Poly (ADP-ribose) polymerases (PARP) in the form of ADP-ribosylation that helps in recognition of DNA breaks and recruitment of enzymes. This study was planned to analyze the expression levels of PARP1 in the sperm samples from both infertile and control (fertile) men and correlate with sperm DNA damage.
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