Abstract
The p57-Kip2 gene encodes a cyclin-dependent kinase inhibitor and hence this gene has received much attention in the study of malignancy. We have analysed expression of this gene in human monocytes and macrophages. In comparison to CD14++ monocytes, p57-Kip2 expression was higher in both CD14+16+ monocytes and alveolar macrophages. p57-Kip2 expression decreased in CD14++ monocytes after stimulation with lipopolysaccharide but increased after incubation with methylprednisolone. The results indicate that p57-Kip2 may be involved in regulating the inflammatory response of monocytic cells.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
