Expression of P53 and Ki67 in gastric cancer tissue and its correlation with therapeutic effect

Abstract

Objective To investigate the expression of P53 and Ki67 in gastric carcinoma and its correlation with therapeutic effect. Methods Seventy cases of gastric cancer patients were selected as the subjects, the patients underwent surgical treatment to get the lesions and cancer tissue and prepare paraffin embedded sections. The expression of P53 and Ki67 in lesion tissues and adjacent tissues were determined by immunohistochemical method, the expression of P53 and Ki67 in different gastric cancer pathology was analyzed. SPSS Pearson correlation analysis software was used to analyze the correlation with therapeutic effect and P53 and Ki67. Results The positive rates of P53 and Ki67 in gastric cancer tissues were higher than those in paracancerous tissues (P 0.05). The positive rates of P53 and Ki67 in gastric carcinoma were closely correlated with tumor size, tumor staging, lymph node metastasis and differentiation (P<0.05); among the 70 cases of gastric cancer, 57 cases had ideal effect after surgical treatment, and 13 cases had poor effect after operation. SPSS Pearson correlation analysis results showed that the therapeutic effect in patients with gastric cancer was positively correlated with the positive rate of P53 and Ki67 (P<0.05). Conclusions P53 and Ki67 are highly expressed in gastric carcinoma. It can be directly involved in the occurrence and development of the disease. Strengthening the determination of P53 and Ki67 levels can evaluate the prognosis of the patients. It is worthy of clinical promotion. Key words: Gastric cancer tissue; P53 protein; Ki67 protein; Therapeutic effect