Abstract
Aims: to evaluate the Expression of NSE and AFI before and after relieving ureteral obstruction in fatal lamb’s lungs with unilateral hydronephrosis. Study Design and Subjects: Forty-five pregnant lambs were randomly divided into 3 groups. Eighteen lambs were in the hydronephrotic model group. The second group included 9 lambs in which ureteral obstruction was relieved 3 weeks after the initial operation. Eighteen lambs were in the control group which was just performed open hysterotomies. Outcome measures: The amniotic fluid index (AFI) and the expression of neuronspecific enolase (NSE) in the lungs were tested. Results: In the hydronephrotic model group, the AFI was less and the expression of NSE was greater than the control group. The AFI and expression of NSE were similar to the control group after relieving the ureteral obstruction. Conclusions: The AFI and expression of NSE return to normal after after relieving the ureteral obstruction, which meant that relieving ureteral obstruction is perhaps beneficial to lung development.
Highlights
Ureteropelvic junction obstruction (UPJO)is a common cause of fetal hydronephrosis; the incidence of UPJO is 1 in 2000 [1]
One type was in the tubular period, and showed multiple tubular structures (Figure 1). Another type of lung tissue was composed of an alveolar structure in the alveolar period (Figure 2), which had deplanatetype I epithelium and cubic-type II epithelium
According to a histologic study, the lungs obtained within 1 week of the initial operation were in the tubular period, while 3 weeks later the lungs were in the alveolar period
Summary
Ureteropelvic junction obstruction (UPJO)is a common cause of fetal hydronephrosis; the incidence of UPJO is 1 in 2000 [1]. Wang [2] reported that relief of ureteral obstruction in utero may prevent or attenuate the development of nephropathy in lambs. In late gestation the amniotic fluid, which benefits lung development, is primarily derived from the kidneys. Harrison [3] and Crombleholme [4] concluded that lung function benefits from relief of ureteral obstruction in utero; the studies had no objective indicator to monitor lung development. During lung development in lambs, NSEpositive cells exist beginning at 5 weeks of gestation. The expression of NSE in fetal lungs with ureteral obstruction has been the subject of a study [8]. The effect of changes in amniotic fluid and expression of NSE in lungs before and after relief of UPJO in utero on lung development were determined
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