Abstract
Objective To investigate the expression of Neuropilin-1 in human pancreatic ductal adenocarcinoma (PDAC) specimens and cell lines. Methods Expression and distribution of Neuropilin-1 were detected in operation tissue specimens of human pancreatic ductal adenocarcinoma with HE, immunohistochemistry and RT-PCR. Results Immunohistochemical analysis revealed that Neuropilin-1 were expressed in human pancreatic adenocarcinoma specimens, precancerous tissue and MIA PaCa-Ⅱ cell lines, but was absent in normal pancreatic tissue, mRNA of Neuropilin-1 could also be detected the in human pancreatic adenocarcinoma specimens, precancerous tissue and MIA PaCaⅡ cell Lines, while could not be detected in normal pancreatic tissue. Neuropilin-1 expression in pancreatic adenocarcinoma were higher than that in normal pancreas, and the differences were significant( P < 0. 01 ). Conclusions Neuropilin-1 might play an potential role in carcinogenesis for pancreatic cancer. Neuropilin-1 may be relevant to perineural invasion of pancreatic carcinoma by some signal transduction. Key words: Neuropilin-l/Bl; Pancreatic neoplasms/ME
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