Abstract
A cytokeratin (CK) +, horizontal basal cell (HBC)-like cell line from murine olfactory epithelium, DBC1.2, was characterized. Histochemically, it is CK14 +, CK18 −, neuron-specific tubulin (NST) + and capable of binding Bandeiraea simplicifolia lectin I. RT-PCR studies revealed that it expresses mRNAs for EGF receptor, NST, Pax-6, but not for Mash-1 and neurogenin-1. Retinoic acid reduced the expression of CK14 and CKs recognized by polyclonal anti-keratin antibody, whereas it induced nestin. These results suggest that DBC1.2 shares the properties of HBCs and neural cells.
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