Abstract
Objective To investigate the expression of nerve growth factor (NGF) in lumbar dorsal root ganglia (DRG) and bladder of streptozotocin-induced diabetic rats before and after treatment.Methods Thirty male Sprague-Dawley (SD) rats were divided into five groups randomly,including 6 in control group,24 in diabetic cystopathy (DC) group.The rat DC models were made throught injection of STZ.The rats in DC group were divided into four subgroups randomly (n =6 each),including DC group,NGF group,RI group,and NRG + RI group.The diabetic rats were treated with NGF and insulin for 4 weeks.NGF was detected in the bladder and DRG by using immunohistochemical staining.Results The blood sugar level in DC group was significantly higher than that in the control group [(30.90 ± 2.33) vs.(4.30 ±0.18) mmol/L (t =30.33,P ＜ 0.01)].The NGF levels in both bladder and DRG of diabetic rats treated with NGF and insulin were significantly increased (0.1492 ± 0.0046 vs.0.1066 ± 0.0055,P＜0.05; 0.1667 ±0.0065 vs.0.1174 ±0.0050,P＜0.05).Conclusion The aberrant expression of NGF in both bladder and DRG of diabetic rats may play an important role,and using exogenous NGF may help to alleviate the pathological changes and improve the function of rats with DC. Key words: Diabetes mellitus; Detrusor; Dorsal root ganglion; Nerve growth factor
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