Abstract
Purpose: Nerve growth factor (NGF) has important functions for the production of pain signals. Depending on which of its two receptors TrkA and p75NTR are activated, NGF also triggers signals of cell differentiation, growth and apoptosis. Stage-related increases of synovial fluid NGF and joint immunohistochemical staining have been described in human osteoarthritis (OA). Animal models are commonly used for OA research, although biochemically and traumatically induced OA in a healthy joint may not be entirely representative of the spontaneous disease process.
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