Abstract
Objective: To evaluate the expressions of Na+-K+-ATPase and calcineurin mRNA and their activities in left ventricular myocardial tissue of renovascular hypertensive rats (RHR), and the effects of intervention with irbesartan. Methods: The renovascular hypertension was induced by “two kidney-one clip” method. RHR were randomly divided into two groups: RHR model group (n=7) and irbesartan-treated group (50mgkg−1d−1, n=7), and sham operation group (n=7) as control. Blood pressure was measured at pre-operation and after operation.
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