Abstract
Introduction: Cyclic AMP (cAMP) is implicated in the proliferation and differentiation of several normal and malignant cell types, including pancreatic cancer. Adenylyl Cyclases (ACs) are enzymes which increase the levels of cAMP when activated. Nine transmembrane AC isoforms are known, and each one has its own pattern of expression and regulation. Objective: In this study we establish which transmembrane AC isoforms are expressed in the pancreatic adenocarcinoma epithelial cell line HPAC. Results: Using RT‐PCR we found five different isoforms: AC1, AC3, AC6, AC7 and AC9. The expression profile is similar to that in pancreatic duct cells, but AC1, which is only expressed in pancreatic cancer cells. Future goals: Study which isoform is involved in the development and progression of HPAC cells. Discussion: Overall, the pathophysiological significance of each AC isoform will provide an important insight into the cellular signaling in pancreatic cancer.
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