Abstract
Mucins, large extracellular proteins that are heavily glycosylated with complex oligosaccharides, establish a selective molecular barrier at the epithelial surface and engage in morphogenetic signal transduction. Alterations in mucin expression or glycosylation accompany the development of cancer and influence cellular growth, differentiation, transformation, adhesion, invasion and immune surveillance. Furthermore, association of MUC1 with p53 in cancer results in inhibition of p53-mediated apoptosis and promotion of p53-mediated cell cycle arrest. In addition, increased expression of MUC1 in cancer cells that promotes cancer cell invasion through beta-catenin, resulting in the initiation of epithelial-mesenchymal transition which promotes the formation of metastases. However, little data are available regarding the role of MUC1 in oral cancers. Then, this study examined the impact of MUC1 against oral squamous cell carcinoma.
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