Expression of MSP58 in human colorectal cancer and its correlation with prognosis

Hai Shi,Shu-Jun Li,Bo Zhang,He-Liang Liu,Chang-Sheng Chen

doi:10.1007/s12032-012-0284-y

Hai Shi, Shu-Jun Li + Show 3 more

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https://doi.org/10.1007/s12032-012-0284-y

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Journal: Medical Oncology	Publication Date: Jul 8, 2012
Citations: 40	License type: cc-by

Affiliation: Air Force Medical University, Xijing Hospital

Abstract

We had reported that MSP58 regulates colorectal cancer cell proliferation, development, and apoptosis, by the cyclin D1-cyclin-dependent kinase 4-p21 pathway. In this study, MSP58 protein expression was examined by immunohistochemistry in 499 specimens of CRC. The relationship between various clinicopathological features and overall patient survival rate was analyzed. The association of MSP58 expression with the 499 CRC patients’ survival rate was assessed by Kaplan–Meier and Cox regression. Using ROC curve to provide sensitivity and specificity of the score of MSP58 predicts local recurrence and survival of CRC patients. The expression of MSP58 was positively correlated with the depth of invasion (P < 0.001), local recurrence (P = 0.008), tumor grade (P = 0.002), and UICC stage (P < 0.001). The Kaplan–Meier survival analysis demonstrated that the survival time of CRC patients with low expression of MSP58 was longer than those with high expression during the 5-year follow-up period (P < 0.001). COX regression analysis indicated that high expression of MSP58 (P < 0.001), depth of invasion >pT1 (P = 0.008), distant organ metastasis (pM1) (P < 0.001), regional lymph node metastasis (≥pN1) (P < 0.001), and local recurrence (Yes) (P = 0.007) were independent, poor prognostic factors of CRC. ROC curve showed the score of MSP58 expression level did provide a maximal sensitivity and specificity to predict local recurrence and survival of CRC patients. Our results demonstrated MSP58 might serve as a novel prognostic marker that is independent of, and additive to, the UICC staging system.

Highlights

Colorectal cancer (CRC) is the fourth most common malignant tumor in China and the fifth most frequent causeMed Oncol (2012) 29:3136–3142 of cancer-related death [1, 2]
We found that the expression of MSP58 was significantly up-regulated in high-grade glioblastoma and colorectal carcinoma tissues, and over-expression of MSP58 was involved in tumor growth, metastasis, cell cycle control, and invasion [14, 15]
We found by average staining score that positive expression of MSP58 in CRC cells was more frequently than adjacent non-cancerous tissue cells, and the expression of MSP58 protein in highly differentiated tumor tissues was lower than in moderately or poorly differentiated CRC tissues

Summary

Introduction

Colorectal cancer (CRC) is the fourth most common malignant tumor in China and the fifth most frequent causeMed Oncol (2012) 29:3136–3142 of cancer-related death [1, 2]. Colorectal cancer (CRC) is the fourth most common malignant tumor in China and the fifth most frequent cause. Despite curative surgical resection of the primary tumor and adjuvant chemotherapy, 40–50 % of the patients die of local recurrence and metastases [3, 4]. Tumor growth and metastasis result from a complex cascade of biological processes. Understanding key factors in these processes is crucial to the design of new treatment modalities. Many molecular markers, including carcinoembryonic antigen (CEA), have been exploited for detecting CRC, these lack sensitivity and specificity for evaluating the prognosis of CRC patients [5,6,7].

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