Abstract
Dihydrodiol dehydrogenase (DD) [EC 1. 3. 1. 20] catalyzes the NADP+-linked oxidation of /trans-dihydrodiols of polycyclic aromatic hydrocarbons to corresponding catechols, and controls the formation of both their carcinogenic dihydrodiol epoxides (Oesch, et al.,, 1984) and cytotoxic o-quinones through autoxidation of the catechol metabolites (Flowers, et al.,., 1996). In addition, DD in mammalian liver is implicated in the metabolism of xenobiotic carbonyl compounds, steroids and prostaglandins because of its broad substrate specificity (Penning, et al.,, 1986; Hara, et al.,, 1986; Ohara, et al.,, 1994; 1995).KeywordsPolycyclic Aromatic HydrocarbonAbundant RabbitDihydrodiol DehydrogenaseCatechol MetaboliteMultiple cDNAsThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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