Abstract
MRGPRX2 is a G protein–coupled receptor that is predominantly expressed in human skin mast cells (MCs).1,2 It is activated by a wide spectrum of cationic ligands including host defense antimicrobial peptides, neuropeptides, Hymenoptera venom, neuromuscular-blocking drugs, and the fluoroquinolone family of antibiotics.3 Systemic mastocytosis (SM) is characterized by the abnormal accumulation of MCs in different organs of the body and may occur with or without cutaneous disease.4 Giavina-Bianchi et al5 recently reported a case of a patient with SM who developed 5 episodes of anaphylaxis in response to insect venom and ciprofloxacin used to treat urinary tract infection.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: The Journal of Allergy and Clinical Immunology: In Practice
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
