Abstract
To investigate the expression of miRNA-4497 in human chorionic villi from early recurrent miscarriage and the influence on apoptosis. The expression of miRNA-4497 in chorionic villi tissues collected from 20 early recurrent miscarriage cases and 20 controls were analyzed using quantitative real-time polymerase chain reaction (qRT-PCR). Human BeWo trophoblastic strains transfected with miRNA-4497 mimic were collected before transfection and 24 h later to measure apoptosis by flow cytometry. miRNA-4497 was up-regulated in early recurrent miscarriage (24.5% ± 5.5% vs 1.1% ± 0.1%, P<0.05), and there was significantly increase in apoptosis after miRNA-4497 mimic transfection (12.2% ± 2.2% vs 7.3% ± 1.2%, P<0.05). Up-regulation of miR-4497 may play an important role in the pathogenesis of recurrent miscarriage. And the pathophysiological mechanism involved should be further studied.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
