Abstract
Objective To investigate the expression of miR-29c-5p in patients with gallbladder cancer (GBC) and to analyze the association of the expression with the clinicopathologic characteristics. Methods The expression levels of miR-29c-5p in 40 patients with GBC along with their matched adjacent tissues were detected by using stem-loop real-time reverse transcription-polymerase chain reaction (qRT-qPCR). The relations of miR-29c-5p expression with the clinicopathologic factors and prognosis of GBC patients were analyzed. Results Compared with tumor-adjacent tissue, the miR-29c-5p expression in GBC was significantly downregulated (Z=-2.521, P=0.008). The expression of miR-29c-5p was closely associated with lynphatic metastasis (χ2=15.140, P 0.05). The average survival period of low and high expression of miR-29c-5p were 7.2 months and 20.2 months. The one-year and three-year survival rate of patients with low expression of miR-29c-5p were significantly lower than those with high levels (32.0%, 16.0% vs 55.7%, 33.4%)(P=0.040). Low miR-29c-5p expression is not risk factor affecting the survival of GBC patients (P=0.974). Conclusions The miR-29c-5p expression is downregulated in GBC tissue, which probably may be associated with the metastasis of GBC, and low miR-29c-5p expression may predict an unfavorable outcome. Key words: Gallbladder neoplasms; Lymphatic metastasis; Gene expression
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