Expression of miR-203 in prostate carcinoma and its correlation with prognosis

Abstract

Objective To explore the expression of miR-203 in prostate carcinoma (PCa) and its correlation with clinicopathological factors and the patients’ prognosis.Methods The expression of miR-203 in 30 cases of PCa and 10 cases of benign prostatic hyperplasia (BPH) were detected by using real-time PCR.Kaplan-Meier and multivariate Cox proportional hazards regression model analysis were applied to compare the survival curves and screen the independent prognosis factors respectively.Results Between the PCa and BPH tissues,there were significant differences in the expression of miR-203 (P ＜ 0.05).With Gleason score getting higher,the levels of miR-203 expression were up-regulated gradually 2 times.Gleason grading ＞ 7 scores vs BPH,Gleasen grading 9-10 scores vs BPH,Gleason grading 7-8 scores vs 7 scores,Gleason grading 9-10 scores vs ＜ 7 scores,the levels of miR-203 expression were up-regulated 2.8,3.1,2.7,2.9 times (all P ＜ 0.05).Moreover,this elevation correlated with Gleason grading,clinical staging and bone metastasis.Furthermore,the survival time was decreased in patients with higher expression levels of miR-203 (P ＜ 0.05).Conclusion Aberrant miRNA expression is partially associated with enhanced malignant degrees and poor prognosis in prostate tumorigenesis.The marker could be applied to indicate the malignant degrees and evaluate the patients’ prognosis. Key words: Prostatic neoplasms; Polymerase chain reaction; Prognosis; miR-203