Abstract
Objective: To explore the expression and clinical significance of miR-155 and miR-146a in psoriasis patients from different sources. Methods: The expression levels of miR-155 and miR-146a in psoriasis vulgaris tissues, peripheral blood mononuclear cells, and serum were detected by the QRT-PCR method in 30 patients with psoriasis vulgaris and 30 healthy subjects as the normal control group, and the correlation between the expression levels of miR-155 and miR-146a in psoriasis samples from different sources was analyzed. And the expression levels of miR-155 and miR-146a in peripheral blood mononuclear cells, and serum after treatment. Results: The expression of miR-155 and miR-146a in skin tissue, peripheral blood mononuclear cells and serum of patients with psoriasis was significantly higher than that of normal controls (P the psoriasis experimental group (P Conclusions: The significantly increased levels of miR-155 and miR-146a in psoriasis samples from different sources may mediate the immune mechanism involved in the activity process of psoriasis.
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