Abstract
This study aimed to explore the role of miR-126 in coronary artery disease (CAD) patients and the potential gene targets of miR-126 in atherosclerosis. A total of 60 CAD patients and 25 healthy control subjects were recruited in this study. Among the 60 CAD patients, 18 cases were diagnosed of stable angina pectoris (SAP), 20 were diagnosed of unstable angina pectoris (UAP) and 22 were diagnosed of acute myocardial infarction (AMI). Plasma miR-126 levels from both groups of participants were analyzed by real-time quantitative PCR. ELISA was used to measure plasma level of placenta growth factor (PLGF). The results showed that the miR-126 expression was significantly down-regulated in the circulation of CAD patients compared with control subjects (P<0.01). Plasma PLGF level was significantly upregulated in patients with unstable angina pectoris and acute myocardial infarction (AMI) compared with controls (both P<0.01) the miR-126 expression in AMI was significantly associated with PLGF. miR-126 may serve as a novel biomarker for CAD.
Highlights
Atherosclerotic coronary artery disease (CAD) is one of the most important causes of sudden cardiac death, accounting for more than 80% of the cases worldwide.[1,2] Despite recent advances in intervention and medication treatments, CAD is still considered to be a severe health threat with high morbidity and mortality worldwide.[3]
Objective: This study aimed to explore the role of miR-126 in coronary artery disease (CAD) patients and the potential gene targets of miR-126 in atherosclerosis
Among the 60 CAD patients, 18 cases were diagnosed of stable angina pectoris (SAP), 20 were diagnosed of unstable angina pectoris (UAP) and 22 were diagnosed of acute myocardial infarction (AMI)
Summary
Atherosclerotic coronary artery disease (CAD) is one of the most important causes of sudden cardiac death, accounting for more than 80% of the cases worldwide.[1,2] Despite recent advances in intervention and medication treatments, CAD is still considered to be a severe health threat with high morbidity and mortality worldwide.[3]. MicroRNAs (miRNAs) are small non-coding RNA molecules of approximately 16-22 nucleotides.[4] Recent researches have demonstrated that miRNAs serve as post-transcriptional regulators of various genes expression through specific interaction with certain messenger RNAs (mRNAs) by inducing degradation or repressing translation of the mRNAs.[5,6] Recently, many studies have shown that miRNA expression could be a valuable signature for predicting the diagnosis and/or prognosis in patients of cardiovascular diseases or cancer.[7,8] In cardiovascular system, miRNAs were observed to be involved in heart and vascular development.[9] it is reasonable to speculate a potential role of miRNA in diagnosis, therapeutic efficacy and prognosis evaluation in patients with CAD. We first investigated the role of miR-126 in atherosclerosis/CAD in this study. We first investigated the role of miR-126 in atherosclerosis/CAD in this study. miR-126 as a positive regulator of several vascular endothelial growth factor (VEGF) family members including
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