Abstract
Background and aimType 1 diabetes mellitus (TIDM) is known for autoimmune destruction of the beta cells, which strongly leads to the lack of insulin production. Increasing evidence suggests that microRNAs (miRNAs) play a role in how T1DM develops, mainly by changing how pancreatic beta-cells work and causing autoreactive agents to build up, which kill beta-cells. Dysregulated microRNA profiles have been identified in children with type 1 diabetes mellitus. This study aims to profile the expression of some miRNAs in T1DM children to evaluate their role in the disease. MethodsMicroRNAs' (30, 451, 130, and 378) expression profiles in the plasma of 50 T1DM children and 50 age and gender-matched healthy volunteer controls were assayed by real-time PCR. ResultsMiRNA-451 and miRNA-378 were significantly upregulated, whereas miRNA-30 and miRNA-130 were significantly downregulated in T1DM patients compared to controls. A significant positive correlation existed between miRNA-30 and FBS and between miRNA-451 and both FBS, 2hPPBS, HbA1c, and disease duration. A significant negative correlation existed between miRNA-451 and the child's age and the onset of T1DM. ConclusionMiRNA-451 and miRNA-378 are upregulated, while miRNA-30 and miRNA-130 are downregulated in T1DM patients and could be used as biomarkers for the disease.
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