Abstract
Objective To investigate the clinicopathologic significance of microRNA (miRNA, miR)-34a expression in hepatocellular carcinomas (HCC). Methods Real-time quantitative polymerase chain reaction (Real-time PCR) was used to quantify miR-34a expression in 59 pairs of HCC tissues and matched normal hepatic tissues. The association of miR-34a expression with the clinicopathologic features was evaluated. Results The expression of miR-34a was significantly downregulated in HCC tissue samples (0.52±0.21) compared to matched normal tissues (5.57±1.48, P<0.05). MiR-34a was highly expressed in HCC with a low pathological grade (Ⅰ-Ⅱ: 0.69±0.22) but markedly decreased in grade (Ⅲ-Ⅳ: 0.32±0.12) tumors (P<0.01). In addition, there was significant difference in the expression of miR-34a between patients with TNM stages Ⅰ-Ⅱ (0.72±0.19) and those with stage Ⅲ-Ⅳ (0.35±0.13) HCC (P<0.01). Conclusion The expression of miR-34a is closely related to the development and progression of HCC. Key words: MicroRNA-34a; MicroRNA; Carcinoma, hepatocellular
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