Abstract

Objective To investigate the expression of microRNA(miRNA, miR)- 1260b in non-small-cell lung carcinoma(NSCLC) and paracarcinoma tissues and the clinical significance. Methods Seventy-eight pairs of lung cancer and paracarcinoma tissues were collected from patients sufferred from NSCLC. MicroRNA microarray was used to screen the miRNA with different expression levels in lung cancer and paracarcinoma tissues. The real-time quantitative polymerase chain reaction(Real-time PCR) was performed to detect the expression of target miRNA with enlarged clinical samples. The clinical analysis was carried out to explore the relationship between miR-1260b and clinical features. Results The ΔCt values of miR-1260b expression in lung cancer and paracarcinoma tissues were 10.04±1.43 and 10.97±1.17, respectively. Compared to paracarcinoma tissues, 82.2% cases showed increased expression of miR- 1260b in lung cancer tissues(P< 0.05). Clinical analysis demonstrated that there was no significant correlation between the expression level of miR-1260b with sex, age, differentiation degree and TNM classification, respectively. Conclusion These results suggested that miR-1260b expression in lung cancer was higher than in paracarcinoma tissues, and may play important roles in the development and progression of lung cancer. Key words: MicroRNA-1260b; Non-small-cell lung carcinoma

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