Abstract
The aim of the study was to study the expression of matrix metalloproteinase-9 (MMP-9) and its tissue inhibitor 1 (TIMP-1) in hepatocytes and nonparenchymal liver cells in neonatal mice of two opposing lines of CBA and C57B1/6 after chronic intrauterine hypoxia. In The total expression level of MMP-9 and TIMP-1 in hepatocyte cells was more pronounced in CBA mice, in compared with mice of the C57B1/6 line.
Highlights
The aim of the study was to study the expression of matrix metalloproteinase-9 (MMP-9) and its tissue inhibitor 1 (TIMP1) in hepatocytes and nonparenchymal liver cells in neonatal mice of two opposing lines of CBA and C57B1/6 after chronic intrauterine hypoxia
In The total expression level of MMP-9 and TIMP-1 in hepatocyte cells was more pronounced in CBA mice, in compared with mice of the C57B1/6 line
В соответствии со стандартизированными протоколами и рекомендациями фирм-производителей антител в парафиновых срезах печени проведены иммуногистохимические исследования с использованием моноклональных антител Rabbit MMP-9, cloneE127 («ThermoFisherScientificInc.», США), MouseaHumanTIMP-1, clone 102D1 («ThermoFisherScientificInc.», Выпуск 3 (67). 2018
Summary
Изучить экспрессию матриксной металлопротеиназы 9 (ММР-9) и ее тканевого ингибитора 1 (TIMP-1) в гепатоцитах и непаренхиматозных клетках печени у новорожденных мышей двух оппозитных линий СВА и С57В1/6, после перенесенной хронической внутриутробной гипоксии (ХВУГ)
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