Abstract
Matrix metalloproteinases (MMPs) are a family of zinc metalloproteinases capable of degrading components of connective tissues. MMP-10 is frequently expressed in human cancers. The aim of this study was to immunohistochemically evaluate its expression in oral squamous cell carcinoma (OSCC) and verrucous carcinoma (OVC). A retrospective analysis of 73 samples (31 OSCC, 22 OVC and 20 non-neoplastic epithelium) was performed. All samples were immunohistochemically stained with monoclonal MMP-10 antibody and expression levels and staining intensity were evaluated with respect to microscopic features. Data were analyzed by SPSS (V.21), Mann-Whitney and Kruskal Wallis tests. MMP-10 was detected in all OSCC and OVC cases. The expression of MMP-10 in OSCC was intensive (score 3) and in OVC was low and moderate (score 1 and score 2) more frequently. Non- neoplastic epithelium did not show MMP-10 expression. Differences between groups was statistically significant (p<0.05). However, the expression of MMP- 10 was not obviously different between various grades of OSCC. According to our study, MMP-10 protein can be important possible factor in the transformation of normal oral epithelium to OVC and OSCC, also the level of MMP-10 expression at invasion front of the lesions can be helpful in the differentiation of OVC and OSCC.
Highlights
Oral Squamous Cell Carcinoma (OSCC) is the most common oral cavity malignancy, which forms 94% of all oral malignancies and about 38% of all head and neck malignant tumors (Henriques et al, 2012; Mohtasham et al, 2013)
Clinical characteristics oral squamous cell carcinoma (OSCC) patients ranged in age from 40 to 75 years, Most patients were female (58%) and most of OSCC cases were located on the gingival and alveolar mucosa of mandible (55.17%) and others located on the buccal mucosa (17.24%), gingival and alveolar mucosa of maxilla (13.79%), Lip mucosa (6.89%), tongue (3.44%) and floor of mouth (3.44%) respectively, and two cases had unspecified location exactly
Matrix metalloproteinases (MMPs)-10 was expressed in all cases of OSCC and Oral Verrucous Carcinoma (OVC) but non neoplastic epithelium did not show MMP10 expression (Figure 1).The immune expression of this protein was confirmed by the presence of brown stained cytoplasm in tumor cells (Figure 2)
Summary
Oral Squamous Cell Carcinoma (OSCC) is the most common oral cavity malignancy, which forms 94% of all oral malignancies and about 38% of all head and neck malignant tumors (Henriques et al, 2012; Mohtasham et al, 2013). Oral Verrucous Carcinoma (OVC) is a low-grade and well-differentiated variant of OSCC that forms 1-10% of OSCC. This lesion has a benign microscopic feature, which is characterized by long rete ridges with abundant production of keratin. The aim of this study was to immunohistochemically evaluate its expression in oral squamous cell carcinoma (OSCC) and verrucous carcinoma (OVC). The expression of MMP-10 in OSCC was intensive (score 3) and in OVC was low and moderate (score 1 and score 2) more frequently. Conclusions: According to our study, MMP-10 protein can be important possible factor in the transformation of normal oral epithelium to OVC and OSCC, the level of MMP-10 expression at invasion front of the lesions can be helpful in the differentiation of OVC and OSCC
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
