Expression of long non-coding RNA H19 in colorectal cancer patients with type 2 diabetes

Abstract

The aim of this study was to explore the lncRNAs expression in colorectal cancer (CRC) patients with type 2 diabetes (T2DM) and evaluate the diagnostic value of lncRNAs expression in CRC patients with T2DM. The present study was conducted on two cohorts with CRC patients. The tissues levels of lncRNAs were measured by real-time PCR analysis. The results showed that H19 and MALAT1 expression were higher in CRC tissues than in normal colorectal mucosa (p = 1.59 × 10−6 and p = 6.95 × 10−9, respectively), whereas lincRNA-p21 showed lower expression in CRC tissues (p = 1.10 × 10−4). Logistic regression analysis results indicated that the expression of H19 was significantly lower in CRC patients with T2DM compared with CRC patients without T2DM (p = .032). H19 expression in CRC group without T2DM was significantly associated with hypertension (p = .040). Additionally, the area under the receiver operating characteristic curve of H19 was 0.672 of the group CRC with T2DM, which suggests that H19 could be a useful biomarker and predictive targets for diagnosis of T2DM in CRC patients.