Abstract

LDL receptor-related proteins (LRPs) are transmembrane receptors involved in endocytosis, cell-signaling, and trafficking of other cellular proteins. Considerable work has focused on LRPs in the fields of vascular biology and neurobiology. How these receptors affect cancer progression in humans remains largely unknown. Herein, we mined provisional databases in The Cancer Genome Atlas (TCGA) to compare expression of thirteen LRPs in ten common solid malignancies in patients. Our first goal was to determine the abundance of LRP mRNAs in each type of cancer. Our second goal was to determine whether expression of LRPs is associated with improved or worsened patient survival. In total, data from 4,629 patients were mined. In nine of ten cancers studied, the most abundantly expressed LRP was LRP1; however, a correlation between LRP1 mRNA expression and patient survival was observed only in bladder urothelial carcinoma. In this malignancy, high levels of LRP1 mRNA were associated with worsened patient survival. High levels of LDL receptor (LDLR) mRNA were associated with decreased patient survival in pancreatic adenocarcinoma. High levels of LRP10 mRNA were associated with decreased patient survival in hepatocellular carcinoma, lung adenocarcinoma, and pancreatic adenocarcinoma. LRP2 was the only LRP for which high levels of mRNA expression correlated with improved patient survival. This correlation was observed in renal clear cell carcinoma. Insights into LRP gene expression in human cancers and their effects on patient survival should guide future research.

Highlights

  • The LDL Receptor (LDLR) gene family includes single-pass, type 1 transmembrane proteins that share common structural motifs, including EGF-like repeats, cysteine-rich complement-like repeats, and sequential YWTD-containing repeats that are organized into β-propeller structures [1,2,3,4,5]

  • To study expression of LDL Receptor-related Proteins (LRPs) in solid malignancies in humans and determine whether expression of LRPs is associated with altered patient survival, we mined provisional The Cancer Genome Atlas (TCGA) datasets

  • We examined the effects of LRP1 mRNA expression on survival in all ten malignancies, LRP1 mRNA expression demonstrated a significant correlation with patient survival only in urothelial carcinoma of the bladder

Read more

Summary

Introduction

The LDL Receptor (LDLR) gene family includes single-pass, type 1 transmembrane proteins that share common structural motifs, including EGF-like repeats, cysteine-rich complement-like repeats, and sequential YWTD-containing repeats that are organized into β-propeller structures [1,2,3,4,5]. Expression of LRPs in cancer in patients

Objectives
Methods
Results
Conclusion
Full Text
Published version (Free)

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call