Abstract
Background and Objective Liver cancer is a common malignant tumor with few poor diagnostic and prognostic markers, which greatly shortens the potential life span of patients. The RNA-binding protein la ribonucleoprotein 4B (LARP4B) has a la motif (lam) that is important in the process of cancer. We aimed to explore the role of LARP4B in the diagnosis and prognosis of liver cancer. Methods The Cancer Genome Atlas (TCGA) database was searched to detect LARP4B gene expression in liver cancer. The clinical relevance and diagnostic ability of LARP4B were evaluated by a chi-squared test and a receiver operating characteristic (ROC) curve, respectively. Survival and risk factors of patients with liver cancer were assessed by survival analysis and univariate/multivariate Cox regression model. Additionally, we carried out gene set enrichment analysis (GSEA) to identify LARP4B-related signaling pathways in liver cancer. Results LARP4B mRNA was highly expressed in liver cancer tissues and was correlated with survival status. The chi-squared test showed that LARP4B had clinical relevance, while ROC curves showed that LARP4B had good diagnostic ability. Survival analysis showed that liver cancer patients with high LARP4B expression had shorter overall/relapse-free survival. The univariate/multivariate Cox regression model indicated that high LARP4B expression may be an independent risk factor for the prognosis of liver cancer patients. Finally, we found that genes involved in the G2M checkpoint, E2F targets, and mitotic spindle were differentially enriched in the high LARP4B-expression phenotype. Conclusions LARP4B is a potential independent biomarker for diagnosis and prognosis in liver cancer patients.
Highlights
Liver cancer is one of the most common malignant tumors in the world [1]
la ribonucleoprotein 4B (LARP4B) expression grouped by vital status Wilcoxon, P = 0.03
LARP4B expression grouped by age T-test, P = 0.0021
Summary
Liver cancer is one of the most common malignant tumors in the world [1]. It has a high degree of malignancy, strong invasion and metastasis, and poor prognosis and poses a serious threat to health [2]. Liver cancer is a common malignant tumor with few poor diagnostic and prognostic markers, which greatly shortens the potential life span of patients. We aimed to explore the role of LARP4B in the diagnosis and prognosis of liver cancer. Survival and risk factors of patients with liver cancer were assessed by survival analysis and univariate/multivariate Cox regression model. We carried out gene set enrichment analysis (GSEA) to identify LARP4B-related signaling pathways in liver cancer. Survival analysis showed that liver cancer patients with high LARP4B expression had shorter overall/relapse-free survival. The univariate/multivariate Cox regression model indicated that high LARP4B expression may be an independent risk factor for the prognosis of liver cancer patients. LARP4B is a potential independent biomarker for diagnosis and prognosis in liver cancer patients
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