Abstract
To investigate the association between CD105 and tumor cell proliferation in salivary gland tumors. In this study, 59 samples of salivary tumors from Khalili Hospital archive, including 20 cases of pleomorphic adenoma (PA), 20 cases of mucoepidermoid carcinoma (MEC) and 19 cases of adenoid cystic carcinoma, as well as 10 cases of normal salivary gland tissue, were reviewed by immunohistochemistry (IHC) for CD105 and Ki67 staining. CD105 positive vessels were absent in normal salivary gland tissue in the vicinity of tumors (51.6% of all tumors were positive). There was a statistically significant difference in frequency of CD105 staining between PA and malignant tumors and between four groups of different lesions (p<0.000) being highest in MEC. Intratumoral microvessel density was also elevated in malignant neoplasms (2.61 ± 3.1) as compared to PA (0.46 ± 0.6). Normal salivary glands did not express Ki67. There was a statistically significant difference in frequency and percentage of Ki67 immunoreactivity in malignant neoplasms (86.5% and 10.7 ± 10.8 respectively) compared to PA (50% and 0.78 ± 0.2) and among the four groups values were highest in MEC (p<0.000). n this study, it was observed a higher rate of angiogenesis and cellular proliferation was noted in malignant tumors compared to benign tumors, but no correlation was observed between these two markers.
Highlights
Angiogenesis, development of new blood vessels from previous blood vessels, is necessary for tumor growth and metastasis
CD105 is a marker that has an important role in angiogenesis (Nassiri et al, 2011) and it is essential for proliferation of endothelial cells and stimulates active phase of angiogenesis (Goumans et al, 2003)
There was a statistically has been observe3d8w.0hich indicates that development of blood31v.e3ssels reflects inv2a3si.v7eness 3o1f.3salivary gland 30.0 significant difference in frequency of CD105 staining tumors. between pleomorphic adenoma (PA) and malignant tumors and between four 0 These findings are consistent with reports of multiple- 0
Summary
Angiogenesis, development of new blood vessels from previous blood vessels, is necessary for tumor growth and metastasis. A lot of effort has been put into identifying markers of angiogenesis (Meng et al, 2012). CD105 is a marker that has an important role in angiogenesis (Nassiri et al, 2011) and it is essential for proliferation of endothelial cells and stimulates active phase of angiogenesis (Goumans et al, 2003). CD105 is a membranous homodimer protein with a molecular weight of 180 KDa, and the gene for this protein is located on chromosome 9 which is expressed on the cell surface (Dallas et al, 2008). There are two isoforms of protein with the capacity of binding to Transforming Growth Factor β (TGF-β) that differ in the cytoplasmic amino acid composition. Most of CD105 functions are likely to be associated with TGF-β signaling , in some processes it is independent of TGF-β signaling (Levi et al, 2011)
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