Abstract
Immune response (Ir) genes are functionally characterized genes which regulate the ability of an individual or inbred strain of a particular species to respond to certain antigens and hypo-thetically to all antigens (Benacerraf & McDevitt 1972). In the mouse, the majority of Ir genes have been mapped to the major histocompatibility complex (H-2), and those located within H-2 all require cooperation among T lymphocytes, B lymphocytes, and accessory cells. Thus, an understanding of the mode of action of Ir genes requires a determination of the cell type(s) which expresses Ir genes and the nature of the product(s) of these genes. Despite numerous investigations, these points remain controversial (Benacerraf & Katz 1975).
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