Abstract
In response to two types of measles virus (MV) antigens, a vaccine strain CAM and a wild strain isolated in 1994, the expression of IL-2 receptor α (CD25) +CD45RO +CD4 + T-lymphocytes (T-cell activation) was analyzed by flow cytometry. In 75 healthy subjects with measles hemagglutination inhibition tests ≥1:16, the percentage of T-cell activation was significantly increased compared with that in seronegative individuals ( p<0.05). Moreover, the T-cell expression was not significantly different among the vaccinated ( n=38), the naturally infected ( n=28) and the subclinically infected (exposed with wild type without history of measles infection and HI titers ≥1:16) ( n=10) groups. T-cell activation stimulated with MV antigens and HI antibody titers persisted for almost 30 years in the vaccinated group. These results suggest that cell-mediated immunity persists for long periods after vaccination and does not be influenced by antigenic drift.
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