Abstract
Aim: To elucidate the clinicopathological and prognostic values of interferon regulatory factor (IRF) family genes in acute myeloid leukemia (AML). Patients & methods: Differential expression analysis and survival analysis from several reliable databases were conductedand further validated using patients with AML. Results: The expression level of IRF1/2/4/5/7/8/9 in patients withAMLwas upregulated, while IRF3/6 expression was downregulated. High IRF1/7/9 expression indicated aworse overall survivalrate. Conclusion: Overexpression of IRF1/7/9 may be associated with poor survival in patients with AML, suggesting that the IRF family may be a promising therapeutic target.
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