Abstract
Microglial cells isolated from newborn rat brain displayed a baseline immunoreactivity for intercellular adhesion molecule-1 (ICAM-1) after 10–20 days in culture. ICAM-1 immunoreactivity was enhanced in a time-dependent fashion by exposing the microglial cells to recombinant rat γ-interferon (γ-IFN; 100 U/ml) or tumor necrosis factor-α (TNF-α; 100 U/ml). We conclude that rat brain macrophages/microglial cells can be induced by γ-IFN and TNF-α to express ICAM-1. This may be relevant in the interaction of microglial cells with other brain cells during inflammation of the central nervous system.
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