Abstract
Objective To explore the function and mechanism of insulin-like growth factor-1 (IGF-1) in the diabetic bladder.Methods Thirty-five male Sprague-Dawley (SD) rats were divided into two groups randomly,including 15 in control group,and 20 in diabetic group.Rat diabetic models were made through injection of STZ.After 11 weeks,the histologic changes of the bladder and lumbosacral dorsal root ganglia (DRG) in rats were observed under light microscopy by hematoxylin and eosin (HE) staining.The expression of IGF-1 was detected by using immunohistochemistry.Results The blood sugar level in diabetic group was significantly higher than that in control group (29.5200 ± 1.6224 vs.4.7333 ±0.6172,P ＜ 0.01).Immunohistochemical resuhs revealed that the expression of IGF-1 in detrusor cells and DRG of diabetic group was significantly decreasedas compared with control group (P ＜ 0.01) ; DRG:(P ＜ 0.01).Conclusion IGF-1 expression in the bladder tissue and DRG of diabetic rats was significantly reduced,which may play an important role in the pathogenesis of diabetic cytostopathy. Key words: Diabetes; Insulin-like growth factor-1 ; Bladder; Detrusor; Dorsal root ganglia
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