Abstract
Objective To determine and evaluate the transformation of the expression of iNOSmRNA in brain following dif-fuse brain injury (DBI). Methods Fifty-five male SD fats were randomly divided into two groups : control (n=5), DBI(they divided into ten groups again, n=5). Diffuse contusion and laceration of brain was produced by Marmarou' s brain injury model. Determine and evaluate the water contained in brain (edema of brain) and the expression of iNOSmRNA by realtime RT-PCR at different time following diffuse brain injury. Results The expression of iNOSmRNA upregulated rapidly followingdiffuse brain injury. The expression of iNOSmRNA got to top at 12 hours. The expression of iNOSmRNA were different among groups by Kurskal - Wallis test, P<0.05. Conclusion The expression of iNOSmRNA upregulates rapidly following diffuse brain injury. It gets to maximum at 12 hours. Key words: Diffuse brain injury; iNOS
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